A carboline derivative as a novel mammalian DNA topoisomerase II targeting agent.
Biochem Pharmacol
; 44(11): 2149-55, 1992 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-1335251
ABSTRACT
The DNA intercalating, ellipticine analog drug, 5,11-dimethyl-5H-indol[2,3-b]quinoline, is able to stabilize in vitro the topoisomerase II-DNA cleavable complex and to induce DNA breaks in BPV I episome in rat fibroblasts. Cytotoxicity studies with DC3F cells resistant to ellipticine strongly suggest that topoisomerase II is a cellular target involved in the mechanism of cytotoxic action of this carboline derivative.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA
/
Carbolines
/
DNA Topoisomerases, Type II
/
Antineoplastic Agents
Limits:
Animals
Language:
En
Journal:
Biochem Pharmacol
Year:
1992
Document type:
Article
Affiliation country:
France