Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

Livingstone, L R; White, A; Sprouse, J; Livanos, E; Jacks, T; Tlsty, T D

Livingstone, L R; White, A; Sprouse, J; Livanos, E; Jacks, T; Tlsty, T D.

Affiliation

Livingstone LR; Lineberger Comprehensive Cancer Center, Department of Pathology, University of North Carolina, School of Medicine, Chapel Hill 27599-7295.

Cell ; 70(6): 923-35, 1992 Sep 18.

Article in En | MEDLINE | ID: mdl-1356076

Subject(s)

Cell Cycle/genetics; Gene Amplification/genetics; Genes, p53/physiology; Animals; Aspartate Carbamoyltransferase/antagonists & inhibitors; Aspartate Carbamoyltransferase/genetics; Aspartic Acid/analogs & derivatives; Aspartic Acid/pharmacology; Base Sequence; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/antagonists & inhibitors; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)/genetics; Cell Cycle/drug effects; Cells, Cultured; Chromosome Deletion; Cytogenetics; Dihydroorotase/antagonists & inhibitors; Dihydroorotase/genetics; Embryo, Mammalian; Fibroblasts; Genes, p53/genetics; Germ Cells; Heterozygote; Humans; Li-Fraumeni Syndrome/genetics; Mice; Mice, Transgenic; Molecular Sequence Data; Multienzyme Complexes/antagonists & inhibitors; Multienzyme Complexes/genetics; Mutation; Phosphonoacetic Acid/analogs & derivatives; Phosphonoacetic Acid/pharmacology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Cell Cycle / Gene Amplification / Genes, p53 Limits: Animals / Humans Language: En Journal: Cell Year: 1992 Document type: Article Country of publication: United States

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