Alzheimer skin fibroblasts show increased susceptibility to free radicals.
Mech Ageing Dev
; 66(2): 117-20, 1992 Nov.
Article
in En
| MEDLINE
| ID: mdl-1365838
ABSTRACT
We have studied the response to toxic oxygen metabolites of fibroblasts derived from skin biopsies of 5 patients with familial (FAD) and 4 with sporadic (AD) Alzheimer's disease compared with those derived from 4 normal controls. Fibroblasts were damaged by the generation of oxygen metabolites during the enzymatic oxidation of acetaldehyde by 50 munits of xanthine-oxidase (Xo). To quantify cell damage we measured lactate dehydrogenase (LDH) activity in the culture medium and cell viability in fibroblast cultures. We found a significant increase in LDH activity in the FAD vs. controls and also in the AD vs. controls.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Reactive Oxygen Species
/
Alzheimer Disease
Limits:
Humans
Language:
En
Journal:
Mech Ageing Dev
Year:
1992
Document type:
Article
Affiliation country:
Italy
Country of publication:
IE
/
IRELAND
/
IRLANDA