Heterodimeric complex formation with CD8 and TCR by bispecific antibody sustains paracrine IL-2-dependent growth of CD3+ CD8+ T cells.

De Lau, W B; Boom, S E; Heije, K; Griffioen, A W; Braakman, E; Bolhuis, R L; Tax, W J; Clevers, H; Bast, B J

De Lau, W B; Boom, S E; Heije, K; Griffioen, A W; Braakman, E; Bolhuis, R L; Tax, W J; Clevers, H; Bast, B J.

Affiliation

De Lau WB; Department of Clinical Immunology, University Hospital, Utrecht, The Netherlands.

J Immunol ; 149(6): 1840-6, 1992 Sep 15.

Article in En | MEDLINE | ID: mdl-1387662

Subject(s)

Antigens, Differentiation, T-Lymphocyte/physiology; CD8 Antigens/physiology; Interleukin-2/physiology; Lymphocyte Activation; Receptors, Antigen, T-Cell/physiology; T-Lymphocyte Subsets/immunology; CD3 Complex; CD8 Antigens/chemistry; Calcium/physiology; Cytotoxicity, Immunologic; Humans; Immunologic Techniques; In Vitro Techniques; Macromolecular Substances; Receptor Aggregation; Receptors, Antigen, T-Cell/chemistry; Signal Transduction; Solubility

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Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / Receptors, Antigen, T-Cell / Antigens, Differentiation, T-Lymphocyte / T-Lymphocyte Subsets / Interleukin-2 / CD8 Antigens Limits: Humans Language: En Journal: J Immunol Year: 1992 Document type: Article Affiliation country: Netherlands

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