Activin can generate ectopic axial structures in chick blastoderm explants.
Development
; 115(3): 689-94, 1992 Jul.
Article
in En
| MEDLINE
| ID: mdl-1425348
ABSTRACT
We have recently shown that activin can induce the formation of axial structures from chick blastulae and that activin beta-B is transcribed, in the hypoblast of the chick, at the same stage that axial mesoderm is being induced. It was not clear, however, whether activin was merely allowing the central epiblastic cells to express a differentiated phenotype for which they were already prepared. This report shows that activin-containing medium (ACM) can act as an instructive inductor, which can change the fate of competent cells and bring about the formation of an ectopic embryonic axis. Furthermore, we show data that suggest that during normal development only one axis is obtained as a result of a carefully controlled inhibitory process.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blastocyst
/
Embryonic Induction
/
Inhibins
/
Mesoderm
Limits:
Animals
Language:
En
Journal:
Development
Journal subject:
BIOLOGIA
/
EMBRIOLOGIA
Year:
1992
Document type:
Article
Affiliation country:
Israel