A reproducible method for producing and quantifying the stages of fracture repair.
Lab Anim Sci
; 42(4): 369-74, 1992 Aug.
Article
in En
| MEDLINE
| ID: mdl-1434497
ABSTRACT
Male CD-1 mice, 4 to 6 months of age, were used to establish a reproducible model to study the stages of fracture repair. A custom-designed fracture apparatus was constructed, and trials with it demonstrated its capacity to reliably reproduce a closed fracture of the tibia. Dietary and sleep habits in the treated mice were the same as unfractured control mice. Four stages of fracture repair were documented and the duration of each stage was quantifiable and reproducible. The last stage of fracture repair was completed by 21 days postfracture. The reproducibility of the fracture, the reproducibility of the times and stages of fracture repair, the relatively short time to complete the fracture repair process, and the minimal discomfort which allowed the mice to maintain a normal daily routine, suggest that this is an ideal animal model for studying the fracture repair process.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tibial Fractures
/
Fracture Healing
/
Disease Models, Animal
/
Fractures, Closed
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Lab Anim Sci
Year:
1992
Document type:
Article
Affiliation country:
Canada