The biosynthesis of dimethyltryptamine in vivo.
Res Commun Chem Pathol Pharmacol
; 16(1): 47-58, 1977 Jan.
Article
in En
| MEDLINE
| ID: mdl-14361
ABSTRACT
The in vivo formation of dimethyltryptamine was studied in rabbits, rats and monkeys. When C14-labelled N-methyltryptamine was administered by intravenous injection to rabbits, C14-dimethyltryptamine was found in lung, the principle site of the methyltransferase that biosynthesizes this psychotogen. Unequivocal evidence for C14-dimethyltryptamine formation in rat tissues was not obtained. When rabbits were given non-radioactive N-methyltryptamine intravenously, dimethyltryptamine appeared in carotid arterail blood, peaking within the first minute after injection of the precursor. USing this assay procedure we could not demonstrate dimethyltryptamine synthesis in the rhesus monkey.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tryptamines
/
N,N-Dimethyltryptamine
Limits:
Animals
Language:
En
Journal:
Res Commun Chem Pathol Pharmacol
Year:
1977
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA