CP-72,588, a semisynthetic analog of the polyether ionophore UK-58,582 with increased anticoccidial potency.
Antimicrob Agents Chemother
; 36(10): 2080-4, 1992 Oct.
Article
in En
| MEDLINE
| ID: mdl-1444288
ABSTRACT
We have employed semisynthesis to enhance the anticoccidial potency of a polyether ionophore. CP-72,588 is the alpha-methyl analog of the fermentation-derived polyether ionophore UK-58,852. The parent ionophore required a dose of 15 ppm to achieve anticoccidial efficacy in chickens equivalent to that of salinomycin at 60 ppm. CP-72,588 demonstrated substantially improved potency, with efficacy at 5 to 7.5 ppm. The intrinsic antimicrobial potencies of the two ionophores are similar; however, CP-72,588 was found in chicken tissues at higher levels than those of the parent ionophore when each was administered at the same dose (8 ppm). The enhanced potency of CP-72,588 may be partially due to enhanced uptake into tissues.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Coccidiosis
/
Coccidiostats
/
Eimeria
/
Ethers, Cyclic
/
Ionophores
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
1992
Document type:
Article