Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation.

Tang, C K; Chin, J; Harford, J B; Klausner, R D; Rouault, T A

Tang, C K; Chin, J; Harford, J B; Klausner, R D; Rouault, T A.

Affiliation

Tang CK; Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.

J Biol Chem ; 267(34): 24466-70, 1992 Dec 05.

Article in En | MEDLINE | ID: mdl-1447194

Subject(s)

Iron/pharmacology; RNA, Messenger/metabolism; RNA-Binding Proteins/metabolism; Animals; Blotting, Western; Cell Line; Cloning, Molecular; Deferoxamine/pharmacology; Escherichia coli/genetics; Ferritins/genetics; Hemin/pharmacology; Humans; Iron-Regulatory Proteins; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; RNA-Binding Proteins/genetics; RNA-Binding Proteins/isolation & purification; Rabbits; Recombinant Fusion Proteins/metabolism; Recombinant Proteins/isolation & purification; Recombinant Proteins/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / RNA-Binding Proteins / Iron Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 1992 Document type: Article Country of publication: United States

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