Acyl-CoA:cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.

Harris, N V; Smith, C; Ashton, M J; Bridge, A W; Bush, R C; Coffee, E C; Dron, D I; Harper, M F; Lythgoe, D J; Newton, C G

Harris, N V; Smith, C; Ashton, M J; Bridge, A W; Bush, R C; Coffee, E C; Dron, D I; Harper, M F; Lythgoe, D J; Newton, C G.

Affiliation

Harris NV; Rhone-Poulenc Rorer, Central Research, Dagenham, Essex, U.K.

J Med Chem ; 35(23): 4384-92, 1992 Nov 13.

Article in En | MEDLINE | ID: mdl-1447739

Subject(s)

Anticholesteremic Agents/chemical synthesis; Imidazoles/chemical synthesis; Sterol O-Acyltransferase/antagonists & inhibitors; Animals; Anticholesteremic Agents/chemistry; Anticholesteremic Agents/pharmacology; Imidazoles/chemistry; Imidazoles/pharmacology; Male; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Sterol O-Acyltransferase / Imidazoles / Anticholesteremic Agents Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1992 Document type: Article Affiliation country: United kingdom

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