Synthetic approaches toward total synthesis of 12 beta-methyl- and 12-methylene-19-norpregnanes.
Steroids
; 57(11): 514-21, 1992 Nov.
Article
in En
| MEDLINE
| ID: mdl-1448810
ABSTRACT
The effect of a substituent in the 12-position of progestagens was studied. To this end, various approaches toward the preparation of 12 beta-alkyl- and 12-alkylidenenorpregnanes were investigated. Eventually, the desired compounds 17 beta-hydroxy-12 beta-methyl-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn-3-one (37) and 17 beta-hydroxy-12-methylene-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn- 3-one (38) were obtained in racemic form by total synthesis; they were shown to lack progestagenic activity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnanes
/
Desogestrel
Language:
En
Journal:
Steroids
Year:
1992
Document type:
Article
Affiliation country:
Netherlands
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA