Improving selection of alphaIIbbeta3-binding phage antibodies with increased reactivity derived from immunized donors.

Jacobin, M J; Robert, R; Pouns, O; Laroche-Traineau, J; Nurden, A; Peter, K; Little, M; Clofent-Sanchez, G

Jacobin, M J; Robert, R; Pouns, O; Laroche-Traineau, J; Nurden, A; Peter, K; Little, M; Clofent-Sanchez, G.

Affiliation

Jacobin MJ; CNRS UMR 5533, Hôpital Cardiologique, Avenue de Magellan, 33604 Pessac, France.

Clin Immunol ; 108(3): 199-210, 2003 Sep.

Article in En | MEDLINE | ID: mdl-14499243

Subject(s)

Platelet Glycoprotein GPIIb-IIIa Complex/immunology; Purpura, Thrombocytopenic, Idiopathic/immunology; Thrombasthenia/immunology; Animals; Antibodies, Monoclonal/immunology; Autoantibodies/genetics; Autoantibodies/immunology; CHO Cells; Clone Cells/immunology; Complementarity Determining Regions/genetics; Cricetinae; Female; Humans; Immunization; Immunoglobulin Heavy Chains/genetics; Immunoglobulin Light Chains/genetics; Male; Middle Aged; Mutation; Oligopeptides/pharmacology; Peptide Library; Somatic Hypermutation, Immunoglobulin; Spleen/cytology; Tissue Donors

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Collection: 01-internacional Database: MEDLINE Main subject: Thrombasthenia / Purpura, Thrombocytopenic, Idiopathic / Platelet Glycoprotein GPIIb-IIIa Complex Limits: Animals / Female / Humans / Male / Middle aged Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2003 Document type: Article Affiliation country: France

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