In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model.

Andes, D; Marchillo, K; Stamstad, T; Conklin, R

Andes, D; Marchillo, K; Stamstad, T; Conklin, R.

Affiliation

Andes D; University of Wisconsin. William S. Middleton Veterans Affairs Hospital, Madison, Wisconsin.

Antimicrob Agents Chemother ; 47(10): 3165-9, 2003 Oct.

Article in En | MEDLINE | ID: mdl-14506026

Subject(s)

Antifungal Agents/pharmacology; Antifungal Agents/pharmacokinetics; Candidiasis/drug therapy; Candidiasis/metabolism; Pyrimidines/pharmacology; Pyrimidines/pharmacokinetics; Triazoles/pharmacology; Triazoles/pharmacokinetics; Administration, Oral; Animals; Area Under Curve; Candida albicans/drug effects; Candida albicans/genetics; Candida albicans/growth & development; Candida albicans/isolation & purification; Candidiasis/blood; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Female; Fluconazole/pharmacology; Kidney/metabolism; Mice; Microbial Sensitivity Tests; Neutropenia/metabolism; Pyrimidines/blood; Triazoles/blood; Voriconazole

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Triazoles / Candidiasis / Antifungal Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2003 Document type: Article Country of publication: United States

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