Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice.

Inagaki, Yutaka; Nemoto, Tomoyuki; Kushida, Miwa; Sheng, Yin; Higashi, Kiyoshi; Ikeda, Kazuo; Kawada, Norifumi; Shirasaki, Fumiaki; Takehara, Kazuhiko; Sugiyama, Kota; Fujii, Mitsukiyo; Yamauchi, Hiroshi; Nakao, Atsuhito; de Crombrugghe, Benoit; Watanabe, Tetsu; Okazaki, Isao

Inagaki, Yutaka; Nemoto, Tomoyuki; Kushida, Miwa; Sheng, Yin; Higashi, Kiyoshi; Ikeda, Kazuo; Kawada, Norifumi; Shirasaki, Fumiaki; Takehara, Kazuhiko; Sugiyama, Kota; Fujii, Mitsukiyo; Yamauchi, Hiroshi; Nakao, Atsuhito; de Crombrugghe, Benoit; Watanabe, Tetsu; Okazaki, Isao.

Affiliation

Inagaki Y; Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Bohseidai, Isehara 259-1193, Japan. yutakai@is.icc.u-tokai.ac.jp

Hepatology ; 38(4): 890-9, 2003 Oct.

Article in En | MEDLINE | ID: mdl-14512876

Subject(s)

Collagen/genetics; Gene Expression Regulation/drug effects; Interferon-alpha/pharmacology; Liver Cirrhosis, Experimental/prevention & control; Animals; Carbon Tetrachloride/toxicity; Cells, Cultured; Collagen Type I; DNA-Binding Proteins/metabolism; Down-Regulation; E1A-Associated p300 Protein; Liver/drug effects; Liver/metabolism; Male; Mice; Mice, Transgenic; Nuclear Proteins/metabolism; Phosphorylation; Promoter Regions, Genetic; Rats; Rats, Wistar; STAT1 Transcription Factor; Trans-Activators/metabolism; Transcription, Genetic/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Collagen / Interferon-alpha / Liver Cirrhosis, Experimental Limits: Animals Language: En Journal: Hepatology Year: 2003 Document type: Article Affiliation country: Japan Country of publication: United States

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