WAY-855 (3-amino-tricyclo[2.2.1.02.6]heptane-1,3-dicarboxylic acid): a novel, EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake.

Dunlop, John; Eliasof, Scott; Stack, Gary; McIlvain, H Beal; Greenfield, Alexander; Kowal, Dianne; Petroski, Robert; Carrick, Tikva

Dunlop, John; Eliasof, Scott; Stack, Gary; McIlvain, H Beal; Greenfield, Alexander; Kowal, Dianne; Petroski, Robert; Carrick, Tikva.

Affiliation

Dunlop J; Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543, USA. Dunlopj@wyeth.com

Br J Pharmacol ; 140(5): 839-46, 2003 Nov.

Article in En | MEDLINE | ID: mdl-14517179

Subject(s)

Excitatory Amino Acid Transporter 2/antagonists & inhibitors; Excitatory Amino Acid Transporter 2/metabolism; Glutamic Acid/metabolism; Heptanes/pharmacology; Heterocyclic Compounds, 3-Ring/pharmacology; Neurotransmitter Uptake Inhibitors/pharmacology; Amino Acid Transport System X-AG/antagonists & inhibitors; Amino Acid Transport System X-AG/metabolism; Animals; CHO Cells; Cell Line; Cricetinae; Dogs; Dose-Response Relationship, Drug; Heptanes/chemistry; Heterocyclic Compounds, 3-Ring/chemistry; Humans; Neurotransmitter Uptake Inhibitors/chemistry; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurotransmitter Uptake Inhibitors / Glutamic Acid / Excitatory Amino Acid Transporter 2 / Heptanes / Heterocyclic Compounds, 3-Ring Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2003 Document type: Article Affiliation country: United States Country of publication: United kingdom

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