Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.

Rosen, Evan D; Kulkarni, Rohit N; Sarraf, Pasha; Ozcan, Umut; Okada, Terumasa; Hsu, Chung-Hsin; Eisenman, Daniel; Magnuson, Mark A; Gonzalez, Frank J; Kahn, C Ronald; Spiegelman, Bruce M

Rosen, Evan D; Kulkarni, Rohit N; Sarraf, Pasha; Ozcan, Umut; Okada, Terumasa; Hsu, Chung-Hsin; Eisenman, Daniel; Magnuson, Mark A; Gonzalez, Frank J; Kahn, C Ronald; Spiegelman, Bruce M.

Affiliation

Rosen ED; Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. erosen@bidmc.harvard.edu

Mol Cell Biol ; 23(20): 7222-9, 2003 Oct.

Article in En | MEDLINE | ID: mdl-14517292

Subject(s)

Glucose/metabolism; Receptors, Cytoplasmic and Nuclear/chemistry; Receptors, Cytoplasmic and Nuclear/metabolism; Transcription Factors/chemistry; Transcription Factors/metabolism; Animals; Blood Glucose/metabolism; Cell Differentiation; Cell Division; Cell Separation; Chromans/pharmacology; Crosses, Genetic; Dose-Response Relationship, Drug; Exons; Flow Cytometry; Glucose Tolerance Test; Hypoglycemic Agents/pharmacology; Immunohistochemistry; Insulin/blood; Insulin/metabolism; Insulin Secretion; Islets of Langerhans/metabolism; Mice; Mice, Knockout; Mice, Transgenic; Receptors, Cytoplasmic and Nuclear/genetics; Thiazolidinediones/pharmacology; Time Factors; Transcription Factors/genetics; Troglitazone

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Receptors, Cytoplasmic and Nuclear / Glucose Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Cell Biol Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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