Use of semipreparative supercritical fluid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers.
J Chromatogr A
; 1011(1-2): 155-61, 2003 Sep 05.
Article
in En
| MEDLINE
| ID: mdl-14518772
ABSTRACT
The semipreparative separation of the albendazole sulfoxide enantiomers using chiral supercritical fluid chromatography is presented in this work. For this purpose, a modular SFC chromatograph was adapted to work at semipreparative scale and a Chiralpak AD (250 x 10 mm) column was used. Different injection volumes were evaluated in order to obtain high purities and throughputs. Using the maximum load, it was possible to obtain 37 mg/h of the first eluted enantiomer with a purity of 99.9%, and 36.5 mg/h of the second eluted enantiomer with a purity of 95%.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Albendazole
/
Chromatography, Supercritical Fluid
Language:
En
Journal:
J Chromatogr A
Year:
2003
Document type:
Article
Affiliation country:
Spain