CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation.
Br J Cancer
; 89(7): 1162-5, 2003 Oct 06.
Article
in En
| MEDLINE
| ID: mdl-14520439
ABSTRACT
Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenous cytokines and may thus ensure protracted stimulation of CML-specific T cells upon vaccination.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dendritic Cells
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Adenoviridae
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
CD40 Antigens
Limits:
Humans
Language:
En
Journal:
Br J Cancer
Year:
2003
Document type:
Article
Affiliation country:
Netherlands