Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.

Ray, Adrian S; Schinazi, Raymond F; Murakami, Eisuke; Basavapathruni, Aravind; Shi, Junxing; Zorca, Suzana M; Chu, Chung K; Anderson, Karen S

Ray, Adrian S; Schinazi, Raymond F; Murakami, Eisuke; Basavapathruni, Aravind; Shi, Junxing; Zorca, Suzana M; Chu, Chung K; Anderson, Karen S.

Affiliation

Ray AS; Department of Pharmacology, Yale University School of Medicine, New Haven, Conn., USA.

Antivir Chem Chemother ; 14(3): 115-25, 2003 May.

Article in En | MEDLINE | ID: mdl-14521328

Subject(s)

Antiviral Agents/chemistry; Deoxycytidine Monophosphate/analogs & derivatives; Deoxycytosine Nucleotides/chemistry; Fluorine/chemistry; HIV Reverse Transcriptase/metabolism; Antiviral Agents/metabolism; Antiviral Agents/pharmacology; Deoxycytidine Monophosphate/metabolism; Deoxycytidine Monophosphate/pharmacology; Deoxycytosine Nucleotides/metabolism; Deoxycytosine Nucleotides/pharmacology; Drug Design; HIV Reverse Transcriptase/antagonists & inhibitors; HIV Reverse Transcriptase/genetics; Humans; Kinetics; Molecular Structure; Stereoisomerism; Templates, Genetic

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Deoxycytidine Monophosphate / Deoxycytosine Nucleotides / HIV Reverse Transcriptase / Fluorine Type of study: Prognostic_studies Limits: Humans Language: En Journal: Antivir Chem Chemother Journal subject: QUIMICA / TERAPIA POR MEDICAMENTOS / VIROLOGIA Year: 2003 Document type: Article Affiliation country: United States

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