Distribution of plutonium particles in the lungs of Mayak workers.
Radiat Prot Dosimetry
; 105(1-4): 81-4, 2003.
Article
in En
| MEDLINE
| ID: mdl-14526932
ABSTRACT
Lung tissues from workers at the Mayak Production Association were examined to determine the distribution of plutonium (Pu) activity in various lung compartments. Stereological sampling methods and autoradiography were used. Pu particles were identified by microscopic examination of autoradiographs and localised in one of six normal anatomic sites and two sites of fibrosis (parenchymal, non-parenchymal). Particle activity was determined by counting the number of tracks emanating from the particles. Over 50% of the Pu activity was localised in sites of fibrosis, which had significantly higher than average activity for the lung. Over 40% of the activity was in lung parenchyma. Activity in the bronchovascular interstitium was significantly lower than average. These results support the hypothesis that Pu activity is not uniformly distributed in the lung, with long-term retained particles concentrated in scars of the lung. The results may significantly affect estimates of dose from inhaled Pu.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Occupational Exposure
/
Plutonium
/
Risk Assessment
/
Inhalation Exposure
/
Air Pollutants, Radioactive
/
Lung
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
/
Europa
Language:
En
Journal:
Radiat Prot Dosimetry
Year:
2003
Document type:
Article
Affiliation country:
United States