Palladium(0)-mediated desymmetrization of meso tetraols: an approach to the C3-C17 bis-oxane segment of phorboxazoles A and B.
Org Lett
; 5(21): 3915-8, 2003 Oct 16.
Article
in En
| MEDLINE
| ID: mdl-14535742
ABSTRACT
[reaction see text] meso-Tetraol bis(allylic acetates) 2 and 5 were synthesized via two-directional chain elongation. A palladium-mediated, ligand-controlled desymmetrization provided the desired bis-oxanes in greater than 98% ee. Bis-oxanes 1 and 4 represent potential synthetic intermediates for the C3-C17 subunits of phorboxazoles A and B.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxazoles
/
Palladium
/
Heterocyclic Compounds, 4 or More Rings
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2003
Document type:
Article
Affiliation country:
United States