Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

McNally, V A; Gbaj, A; Douglas, K T; Stratford, I J; Jaffar, M; Freeman, S; Bryce, R A

McNally, V A; Gbaj, A; Douglas, K T; Stratford, I J; Jaffar, M; Freeman, S; Bryce, R A.

Affiliation

McNally VA; School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.

Bioorg Med Chem Lett ; 13(21): 3705-9, 2003 Nov 03.

Article in En | MEDLINE | ID: mdl-14552762

Subject(s)

Enzyme Inhibitors/pharmacology; Escherichia coli/enzymology; Hydrazines/chemical synthesis; Hydrazines/pharmacology; Imidazoles/chemical synthesis; Imidazoles/pharmacology; Thymidine Phosphorylase/antagonists & inhibitors; Binding Sites; Computer Simulation; Crystallography, X-Ray; Databases, Genetic; Drug Design; Drug Evaluation, Preclinical; Humans; Kinetics; Models, Molecular; Recombinant Proteins/chemistry; Structure-Activity Relationship; Thymidine/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Thymidine Phosphorylase / Enzyme Inhibitors / Escherichia coli / Hydrazines / Imidazoles Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: United kingdom

Search on Google

Add to My VHL

XML

PubMed Links