[Effect of mexiletine on energy metabolism of ischemic brain in mice].
Zhongguo Yao Li Xue Bao
; 13(4): 354-6, 1992 Jul.
Article
in Zh
| MEDLINE
| ID: mdl-1456059
ABSTRACT
After 30 s ischemia induced by decapitation, the contents of ATP and phosphocreatine (PC) in mouse brain reduced, while that of lactic acid (LA) increased. When mexiletine (3.1-50 mg.kg-1) was injected ip 30 min before decapitation, the brain ATP and PC reduction, and LA accumulation were both alleviated in a dose-dependent manner. These findings suggested that mexiletine was effective in ameliorating the energy exhaustion in the ischemic brain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Ischemia
/
Energy Metabolism
/
Mexiletine
Limits:
Animals
Language:
Zh
Journal:
Zhongguo Yao Li Xue Bao
Year:
1992
Document type:
Article
Affiliation country:
China