Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines.

Buecher, B; Broquet, A; Bouancheau, D; Heymann, M F; Jany, A; Denis, M G; Bonnet, C; Galmiche, J P; Blottière, H M

Buecher, B; Broquet, A; Bouancheau, D; Heymann, M F; Jany, A; Denis, M G; Bonnet, C; Galmiche, J P; Blottière, H M.

Affiliation

Buecher B; INSERM, Human Nutrition Research Center, Department of Gastroenterology, CHU Hôtel-Dieu, Nantes, France.

Dig Liver Dis ; 35(8): 557-65, 2003 Aug.

Article in En | MEDLINE | ID: mdl-14567460

Subject(s)

Adenocarcinoma/metabolism; Cell Division/drug effects; Colorectal Neoplasms/metabolism; Cyclooxygenase Inhibitors/pharmacology; Nitrobenzenes/pharmacology; Sulfonamides/pharmacology; Apoptosis; Blotting, Western; Cell Cycle Proteins/biosynthesis; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases/antagonists & inhibitors; Cyclins/biosynthesis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Enzyme Inhibitors/metabolism; Flow Cytometry; G1 Phase/drug effects; Humans; Isoenzymes/metabolism; Membrane Proteins; Prostaglandin-Endoperoxide Synthases/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Tumor Suppressor Proteins/biosynthesis

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Colorectal Neoplasms / Adenocarcinoma / Cell Division / Cyclooxygenase Inhibitors / Nitrobenzenes Limits: Humans Language: En Journal: Dig Liver Dis Journal subject: GASTROENTEROLOGIA Year: 2003 Document type: Article Affiliation country: France Country of publication: Netherlands

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