Treatment of perioral dystonia with botulinum toxin in 4 cases of Meige's syndrome.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
; 96(5): 544-9, 2003 Nov.
Article
in En
| MEDLINE
| ID: mdl-14600688
ABSTRACT
OBJECTIVE:
We describe the treatment of 4 patients (median age, 53.5 years) with incapacitating perioral dystonia and insufficient response to peroral medication. Their general treatment with clonazepam and anticholinergics was supplemented by intramuscular injections with botulinum toxin A (20-40 U) in the orbicularis oris muscle, guided by electromyography (EMG). STUDYDESIGN:
Perioral dystonia and treatment effect were assessed by using subjective global and visual analog scales, examiner-based video movement counts and rating scales, and quantitative EMG. t Tests were used for statistical analysis.RESULTS:
The result of the intramuscular botulinum toxin A injections was characterized by the patients as "much improved"; correspondingly, dystonia was significantly reduced in visual analog scale scores, on examiner-based assessments, and in recordings of EMG. The side effects were few and short-lasting.CONCLUSION:
Incapacitating perioral dystonia in Meige's syndrome may be safely controlled by recurrent EMG-guided botulinum toxin A injections in the orbicularis oris muscle, in combination with general medication.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Botulinum Toxins, Type A
/
Dystonia
/
Lip Diseases
/
Meige Syndrome
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Year:
2003
Document type:
Article
Affiliation country:
Denmark