A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing.

Li, Mei; Ke, Hua Zhu; Qi, Hong; Healy, David R; Li, Yan; Crawford, D Todd; Paralkar, Vishwas M; Owen, Thomas A; Cameron, Kimberly O; Lefker, Bruce A; Brown, Thomas A; Thompson, David D

Li, Mei; Ke, Hua Zhu; Qi, Hong; Healy, David R; Li, Yan; Crawford, D Todd; Paralkar, Vishwas M; Owen, Thomas A; Cameron, Kimberly O; Lefker, Bruce A; Brown, Thomas A; Thompson, David D.

Affiliation

Li M; Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton Laboratories, Groton, Connecticut 06340, USA.

J Bone Miner Res ; 18(11): 2033-42, 2003 Nov.

Article in En | MEDLINE | ID: mdl-14606517

Subject(s)

Bone and Bones/drug effects; Dinoprostone/agonists; Femoral Fractures/drug therapy; Fracture Healing/drug effects; Pyridines/pharmacology; Pyridines/therapeutic use; Receptors, Prostaglandin E/metabolism; Animals; Bone and Bones/physiology; Disease Models, Animal; Fluorescence; Injections; Male; Molecular Structure; Pyridines/administration & dosage; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E, EP2 Subtype; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Bone and Bones / Dinoprostone / Fracture Healing / Receptors, Prostaglandin E / Femoral Fractures Limits: Animals Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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