Effect of hydroxypropyl beta cyclodextrin complexation on aqueous solubility, stability, and corneal permeation of acyl ester prodrugs of ganciclovir.

Tirucherai, Giridhar S; Mitra, Ashim K

Tirucherai, Giridhar S; Mitra, Ashim K.

Affiliation

Tirucherai GS; Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5005 Rockhill Road, Kansas City, MO 64110, USA.

AAPS PharmSciTech ; 4(3): E45, 2003.

Article in En | MEDLINE | ID: mdl-14621977

Subject(s)

Cornea/metabolism; Cyclodextrins/chemistry; Ganciclovir/analogs & derivatives; Ganciclovir/chemistry; Prodrugs/chemistry; beta-Cyclodextrins; 2-Hydroxypropyl-beta-cyclodextrin; Animals; Carboxylic Acids/chemistry; Chemistry, Pharmaceutical; Drug Stability; Ganciclovir/metabolism; In Vitro Techniques; Male; Permeability/drug effects; Prodrugs/metabolism; Rabbits; Solubility

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Ganciclovir / Cornea / Cyclodextrins / Beta-Cyclodextrins Limits: Animals Language: En Journal: AAPS PharmSciTech Journal subject: FARMACOLOGIA Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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