Structure-activity relationship in the oxazolidinone-quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action.

Hubschwerlen, Christian; Specklin, Jean-Luc; Baeschlin, Daniel K; Borer, Yves; Haefeli, Sascha; Sigwalt, Christine; Schroeder, Susanne; Locher, Hans H

Hubschwerlen, Christian; Specklin, Jean-Luc; Baeschlin, Daniel K; Borer, Yves; Haefeli, Sascha; Sigwalt, Christine; Schroeder, Susanne; Locher, Hans H.

Affiliation

Hubschwerlen C; Morphochem AG, Schwarzwaldallee 215, CH 4058, Basel, Switzerland. christian.hubschwerlen@morphochem.ch

Bioorg Med Chem Lett ; 13(23): 4229-33, 2003 Dec 01.

Article in En | MEDLINE | ID: mdl-14623007

Subject(s)

Anti-Bacterial Agents/pharmacology; Drug Resistance, Bacterial; Gram-Negative Bacteria/drug effects; Gram-Positive Bacteria/drug effects; Oxazolidinones/pharmacology; Quinolones/pharmacology; Acetamides/pharmacology; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/chemistry; DNA Topoisomerase IV/antagonists & inhibitors; Linezolid; Microbial Sensitivity Tests; Molecular Structure; Oxazolidinones/chemical synthesis; Oxazolidinones/chemistry; Quinolones/chemical synthesis; Quinolones/chemistry; Structure-Activity Relationship

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Quinolones / Oxazolidinones / Drug Resistance, Bacterial / Gram-Negative Bacteria / Gram-Positive Bacteria / Anti-Bacterial Agents Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2003 Document type: Article Affiliation country: Switzerland

Search on Google

Add to My VHL

XML

PubMed Links