[Sonografic evaluation of oxygenation in head and neck cancer]. / Abschätzung der Oxygenierung von Kopf-Hals-Karzinomenmetastasen mittels Farbduplexsonographie. Ein neues nicht-invasives Verfahren.
Laryngorhinootologie
; 82(11): 775-81, 2003 Nov.
Article
in De
| MEDLINE
| ID: mdl-14634895
ABSTRACT
BACKGROUND:
Tumor oxygenation is an important aspect of radiosensitivity. The authors describe a new method for a non-invasive assessment of tumor oxygenation in head and neck cancer. PATIENTS ANDMETHODS:
A group of 20 patients with neck metastases of squamous cell cancer of the head and neck region was surveyed. At first a pO (2)-polarography was performed in the metastatic cervical nodes to investigate the tissue oxygenation. In a second step, the vascularisation of these nodes was visualised by color duplex sonography. In order to evaluate the extent of vascularisation in these nodes, the density of color pixels was quantified by a custom-made software program. The color pixel density and the pO (2) values were correlated and the statistic significance was calculated by Pearson's test.RESULTS:
The mean vascularisation as evaluated by the means of color duplex sonography was 7.78 % [95 % CI 6.04 - 9.51]. The interindividual pO (2) values in the stroma of metastatic lymph nodes ranged between 9.0 and 27.4 mmHg (16.6 [95 % CI 14.06 - 19.13]). The mean values of pO (2)-fractions < 2.5/< 5.0/10 mm Hg were 32.25 %, 44.25 % and 53.29 % respectively. The median value of the pO (2)-fraction was 10.49 % [95 % CI 7.13 - 13.85]. The vascularisation as evaluated by color pixel density showed a statistically significant correlation with the pO (2)-fractions < 5.0 and < 10 mmHg (p < 0.045 and < 0.0001) and with the mean (p < 0.002) and median values of tissue pO (2) values (p < 0.0001) in polarography.CONCLUSION:
The results in a limited number of patients suggest, that the proposed sonographic method allows a reliable non-invasive evaluation of tissue oxygenation in cervical metastases of squamous cell head and neck cancers.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen
/
Neoplasms, Squamous Cell
/
Head and Neck Neoplasms
/
Lymphatic Metastasis
Type of study:
Evaluation_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
De
Journal:
Laryngorhinootologie
Journal subject:
OTORRINOLARINGOLOGIA
Year:
2003
Document type:
Article
Affiliation country:
Germany