New bioactive polyphenols from Theobroma grandiflorum ("cupuaçu").
J Nat Prod
; 66(11): 1501-4, 2003 Nov.
Article
in En
| MEDLINE
| ID: mdl-14640528
ABSTRACT
Activity-guided fractionation of Theobroma grandiflorum ("cupuaçu") seeds resulted in the identification of two new sulfated flavonoid glycosides, theograndins I (1) and II (2). In addition, nine known flavonoid antioxidants, (+)-catechin, (-)-epicatechin, isoscutellarein 8-O-beta-d-glucuronide, hypolaetin 8-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide 6' '-methyl ester, quercetin, kaempferol, and isoscutellarein 8-O-beta-d-glucuronide 6' '-methyl ester, were identified. Theograndin II (2) displayed antioxidant activity (IC(50) = 120.2 microM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay, as well as weak cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC(50) values of 143 and 125 microM, respectively. While 1 was less active as an antioxidant than 2, the known compounds were more potent in the DPPH assay (IC(50) range 39.7-89.7 microM).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Flavonoids
/
Malvaceae
/
Glycosides
/
Antineoplastic Agents, Phytogenic
/
Antioxidants
Limits:
Humans
Country/Region as subject:
America do sul
/
Guyana francesa
Language:
En
Journal:
J Nat Prod
Year:
2003
Document type:
Article
Affiliation country:
United States