Synthesis and biological activity of 5'-aminobenzoxazinorifamycin derivatives.
Chem Pharm Bull (Tokyo)
; 40(10): 2707-11, 1992 Oct.
Article
in En
| MEDLINE
| ID: mdl-1464100
ABSTRACT
Benzoxazinorifamycin reacted with various secondary amines to yield various 5'-substituted aminobenzoxazinorifamycin derivatives. The derivatives exhibited potent activities against gram-positive bacteria and mycobacteria. The antimicrobial activities of these compounds against Mycobacterium tuberculosis and Mycobacterium intracellulare were superior to those of rifampicin. Some of these compounds showed good plasma levels after oral administration in rats.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rifamycins
/
Antibiotics, Antitubercular
Limits:
Animals
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
1992
Document type:
Article
Affiliation country:
Japan