Serine 447 in the carboxyl tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor.

Marie, Jean-Claude; Rouyer-Fessard, Christiane; Couvineau, Alain; Nicole, Pascal; Devaud, Hélène; El Benna, Jamel; Laburthe, Marc

Marie, Jean-Claude; Rouyer-Fessard, Christiane; Couvineau, Alain; Nicole, Pascal; Devaud, Hélène; El Benna, Jamel; Laburthe, Marc.

Affiliation

Marie JC; INSERM U410, Faculté de Médecine Xavier Bichat, 75018 Paris, France. ugh@bichat.inserm.fr

Mol Pharmacol ; 64(6): 1565-74, 2003 Dec.

Article in En | MEDLINE | ID: mdl-14645688

Subject(s)

Peptide Fragments/metabolism; Receptors, Vasoactive Intestinal Peptide/agonists; Receptors, Vasoactive Intestinal Peptide/metabolism; Serine/metabolism; Amino Acid Sequence/genetics; Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Humans; Molecular Sequence Data; Peptide Fragments/genetics; Protein Structure, Tertiary/genetics; Receptors, Vasoactive Intestinal Peptide/chemistry; Receptors, Vasoactive Intestinal Peptide/genetics; Receptors, Vasoactive Intestinal Polypeptide, Type I; Serine/chemistry; Serine/genetics; Vasoactive Intestinal Peptide/metabolism; Vasoactive Intestinal Peptide/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Serine / Receptors, Vasoactive Intestinal Peptide Limits: Animals / Humans Language: En Journal: Mol Pharmacol Year: 2003 Document type: Article Affiliation country: France

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