Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells.

Kempuraj, Duraisamy; Huang, Man; Kandere-Grzybowska, Kristiana; Basu, Subimal; Boucher, William; Letourneau, Richard; Athanassiou, Achilles; Theoharides, Theoharis C

Kempuraj, Duraisamy; Huang, Man; Kandere-Grzybowska, Kristiana; Basu, Subimal; Boucher, William; Letourneau, Richard; Athanassiou, Achilles; Theoharides, Theoharis C.

Affiliation

Kempuraj D; Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts-New England Medical Center, Boston, MA 02111, USA.

Int Arch Allergy Immunol ; 132(3): 231-9, 2003 Nov.

Article in En | MEDLINE | ID: mdl-14646384

Subject(s)

Calcium/metabolism; Histamine H1 Antagonists/pharmacology; Interleukin-6/metabolism; Interleukin-8/metabolism; Mast Cells/drug effects; NF-kappa B/metabolism; Phthalazines/pharmacology; Tumor Necrosis Factor-alpha/metabolism; Cells, Cultured; Humans; Mast Cells/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Phthalazines / Calcium / Interleukin-8 / NF-kappa B / Interleukin-6 / Tumor Necrosis Factor-alpha / Histamine H1 Antagonists / Mast Cells Limits: Humans Language: En Journal: Int Arch Allergy Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2003 Document type: Article Affiliation country: United States Country of publication: Switzerland

Search on Google

Add to My VHL

XML

PubMed Links