8-OH-DPAT as a 5-HT7 agonist: phase shifts of the circadian biological clock through increases in cAMP production.

Sprouse, Jeffrey; Reynolds, Linda; Li, Xingfang; Braselton, John; Schmidt, Anne

Sprouse, Jeffrey; Reynolds, Linda; Li, Xingfang; Braselton, John; Schmidt, Anne.

Affiliation

Sprouse J; Pfizer Global Research & Development, Groton, CT 06340, USA. sprousejs@groton.pfizer.com

Neuropharmacology ; 46(1): 52-62, 2004 Jan.

Article in En | MEDLINE | ID: mdl-14654097

Subject(s)

8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology; Circadian Rhythm/drug effects; Cyclic AMP/analogs & derivatives; Cyclic AMP/metabolism; Receptors, Serotonin/metabolism; Serotonin Receptor Agonists/pharmacology; Animals; Binding Sites/drug effects; Cell Line; Competitive Bidding/methods; Cyclic AMP/antagonists & inhibitors; Cyclic AMP/pharmacology; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Embryo, Mammalian; Humans; In Vitro Techniques; Kidney; Male; Neurons/drug effects; Neurons/physiology; Rats; Rats, Sprague-Dawley; Serotonin/pharmacokinetics; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/pharmacokinetics; Suprachiasmatic Nucleus/cytology; Thionucleotides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Serotonin / Circadian Rhythm / 8-Hydroxy-2-(di-n-propylamino)tetralin / Serotonin Receptor Agonists / Cyclic AMP Limits: Animals / Humans / Male Language: En Journal: Neuropharmacology Year: 2004 Document type: Article Affiliation country: United States Country of publication: United kingdom

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