Effect of omeprazole on the anticoagulant activity and the pharmacokinetics of warfarin enantiomers in rats.

Zhou, Qingyu; Chan, Eli

Zhou, Qingyu; Chan, Eli.

Affiliation

Zhou Q; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.

Eur J Pharm Sci ; 20(4-5): 439-49, 2003 Dec.

Article in En | MEDLINE | ID: mdl-14659488

Subject(s)

Anti-Ulcer Agents/pharmacology; Anticoagulants/pharmacology; Anticoagulants/pharmacokinetics; Omeprazole/pharmacology; Warfarin/pharmacology; Warfarin/pharmacokinetics; Algorithms; Animals; Anticoagulants/urine; Biotransformation; Drug Interactions; Hydroxylation; In Vitro Techniques; Indicators and Reagents; Male; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Oxidation-Reduction; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Warfarin/urine

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Collection: 01-internacional Database: MEDLINE Main subject: Warfarin / Omeprazole / Anti-Ulcer Agents / Anticoagulants Limits: Animals Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2003 Document type: Article Affiliation country: Singapore Country of publication: Netherlands

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