Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease.

Weiss, S M; Benwell, K; Cliffe, I A; Gillespie, R J; Knight, A R; Lerpiniere, J; Misra, A; Pratt, R M; Revell, D; Upton, R; Dourish, C T

Weiss, S M; Benwell, K; Cliffe, I A; Gillespie, R J; Knight, A R; Lerpiniere, J; Misra, A; Pratt, R M; Revell, D; Upton, R; Dourish, C T.

Affiliation

Weiss SM; Vernalis Research Ltd., Wokingham, UK. s.weiss@vernalis.com

Neurology ; 61(11 Suppl 6): S101-6, 2003 Dec 09.

Article in En | MEDLINE | ID: mdl-14663021

Subject(s)

Adenosine A2 Receptor Antagonists; Adenosine/analogs & derivatives; Antiparkinson Agents/therapeutic use; Parkinsonian Disorders/drug therapy; Purines/therapeutic use; Pyrimidines/therapeutic use; Adenosine/chemistry; Adenosine/therapeutic use; Animals; Antiparkinson Agents/chemistry; Binding, Competitive/drug effects; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mefloquine/chemistry; Mefloquine/therapeutic use; Mice; Motor Activity/drug effects; Neuroprotective Agents/chemistry; Neuroprotective Agents/therapeutic use; Parkinsonian Disorders/chemically induced; Phenethylamines/chemistry; Phenethylamines/therapeutic use; Purines/chemistry; Pyrimidines/chemistry; Radioligand Assay; Rats; Triazines/chemistry; Triazines/therapeutic use; Triazoles/chemistry; Triazoles/therapeutic use

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Collection: 01-internacional Database: MEDLINE Main subject: Purines / Pyrimidines / Adenosine / Parkinsonian Disorders / Adenosine A2 Receptor Antagonists / Antiparkinson Agents Limits: Animals / Humans Language: En Journal: Neurology Year: 2003 Document type: Article Affiliation country: United kingdom Country of publication: United States

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