In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.

Sun, Xinghua; Yang, Zhijian; Li, Shukuan; Tan, Yuying; Zhang, Nan; Wang, Xiaoen; Yagi, Shigeo; Yoshioka, Takayuki; Takimoto, Akio; Mitsushima, Kenji; Suginaka, Akinori; Frenkel, Eugene P; Hoffman, Robert M

Sun, Xinghua; Yang, Zhijian; Li, Shukuan; Tan, Yuying; Zhang, Nan; Wang, Xiaoen; Yagi, Shigeo; Yoshioka, Takayuki; Takimoto, Akio; Mitsushima, Kenji; Suginaka, Akinori; Frenkel, Eugene P; Hoffman, Robert M.

Affiliation

Sun X; AntiCancer, Inc, San Diego, California 92111, USA.

Cancer Res ; 63(23): 8377-83, 2003 Dec 01.

Article in En | MEDLINE | ID: mdl-14678999

Subject(s)

Carbon-Sulfur Lyases/pharmacology; Polyethylene Glycols/pharmacology; Pyridoxal Phosphate/pharmacology; Succinimides/pharmacology; Animals; Antibodies/blood; Antibody Specificity; Carbon-Sulfur Lyases/chemistry; Carbon-Sulfur Lyases/immunology; Chemistry, Pharmaceutical; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Fluorescamine/metabolism; Half-Life; Methionine/blood; Methionine/deficiency; Mice; Mice, Nude; Polyethylene Glycols/chemistry; Polyethylene Glycols/pharmacokinetics; Recombinant Proteins/chemistry; Recombinant Proteins/pharmacology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Succinimides/chemistry; Succinimides/pharmacokinetics

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Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Pyridoxal Phosphate / Succinimides / Carbon-Sulfur Lyases Limits: Animals Language: En Journal: Cancer Res Year: 2003 Document type: Article Affiliation country: United States Country of publication: United States

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