Difference in mGluR5 interaction between positive allosteric modulators from two structural classes.

Williams, David L; O'Brien, Julie A; Lemaire, Wei; Chen, Tsing-Bau; Chang, Raymond S L; Jacobson, Marlene A; Ha, Sookhee N; Wisnoski, David D; Lindsley, Craig W; Sur, Cyrille; Duggan, Mark E; Pettibone, Douglas J; Conn, P Jeffrey

Williams, David L; O'Brien, Julie A; Lemaire, Wei; Chen, Tsing-Bau; Chang, Raymond S L; Jacobson, Marlene A; Ha, Sookhee N; Wisnoski, David D; Lindsley, Craig W; Sur, Cyrille; Duggan, Mark E; Pettibone, Douglas J; Conn, P Jeffrey.

Affiliation

Williams DL; Department of Neuroscience-WP, Merck Research Laboratories, West Point, Pennsylvania and Rahway, New Jersey. david_williams1@merck.com

Ann N Y Acad Sci ; 1003: 481-4, 2003 Nov.

Article in En | MEDLINE | ID: mdl-14684495

Subject(s)

Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Glycine/analogs & derivatives; Receptors, Metabotropic Glutamate/drug effects; Animals; Benzamides/pharmacology; Binding Sites; CHO Cells; Cricetinae; Excitatory Amino Acid Agonists/chemistry; Excitatory Amino Acid Antagonists/chemistry; Glycine/pharmacology; Humans; Hydrazines/pharmacology; Phthalimides/pharmacology; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate/chemistry; Resorcinols/pharmacology; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Excitatory Amino Acid Antagonists / Excitatory Amino Acid Agonists / Glycine Limits: Animals / Humans Language: En Journal: Ann N Y Acad Sci Year: 2003 Document type: Article

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