Catalytic roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in lornoxicam 5'-hydroxylation.

Iida, Izumi; Miyata, Atsunori; Arai, Masayuki; Hirota, Mitsuyo; Akimoto, Masayuki; Higuchi, Shohei; Kobayashi, Kaoru; Chiba, Kan

Iida, Izumi; Miyata, Atsunori; Arai, Masayuki; Hirota, Mitsuyo; Akimoto, Masayuki; Higuchi, Shohei; Kobayashi, Kaoru; Chiba, Kan.

Affiliation

Iida I; Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd., 403, Yoshino-cho 1-chome, Saitama-shi, Saitama 330-8530, Japan. Izumi.Iida@po.rd.taisho.co.jp

Drug Metab Dispos ; 32(1): 7-9, 2004 Jan.

Article in En | MEDLINE | ID: mdl-14709614

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/metabolism; Aryl Hydrocarbon Hydroxylases/metabolism; Piroxicam/analogs & derivatives; Piroxicam/metabolism; Alleles; Animals; Aryl Hydrocarbon Hydroxylases/genetics; Baculoviridae/enzymology; Baculoviridae/genetics; Catalysis; Cytochrome P-450 CYP2C9; Genotype; Humans; Hydroxylation; In Vitro Techniques; Insecta/metabolism; Isoenzymes/genetics; Isoenzymes/metabolism; Kinetics; Microsomes, Liver/enzymology; Recombinant Proteins/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Aryl Hydrocarbon Hydroxylases / Piroxicam / Anti-Inflammatory Agents, Non-Steroidal Limits: Animals / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2004 Document type: Article Affiliation country: Japan Country of publication: United States

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