Comparative pharmacokinetics of acetyl salicylic acid and its metabolites in children suffering from autoimmune diseases.
Biopharm Drug Dispos
; 25(1): 1-7, 2004 Jan.
Article
in En
| MEDLINE
| ID: mdl-14716747
ABSTRACT
UNLABELLED The aim of the present study was to compare the effect produced by juvenile rheumatoid arthritis (JRA) or rheumatic fever (RF) on the pharmacokinetics of acetyl salicylic acid (ASA) and its metabolites in children with autoimmune diseases (AD). METHODS:
A prospective, open labelled study was performed in 17 children with JRA and 17 with RF who received a single dose of 25 mg ASA/kg orally. The pharmacokinetics of ASA and its metabolites were determined. The blood and urine levels of each salicylate collected during 24 h were measured by HPLC. A group of 15 healthy teenage volunteers was included as a control group.RESULTS:
The maximum plasma concentration, half-life time, area under the curve and the amount of salicylates excreted were statistically different between the JRA and the RF groups, as well as between the RF group and the controls, however, there were no significant differences between the JRA group and the controls.CONCLUSIONS:
Dosage schemes must be adjusted for JRA patients, since the half life in these patients is longer than in RF patients. However, due to ample variability of pharmacokinetic parameters it is recommended that dose schemes are individualized on the type of autoimmune disease considered.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Juvenile
/
Rheumatic Fever
/
Autoimmune Diseases
/
Aspirin
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
En
Journal:
Biopharm Drug Dispos
Year:
2004
Document type:
Article
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM