Effects of an epitope-specific CD8+ T-cell response on murine coronavirus central nervous system disease: protection from virus replication and antigen spread and selection of epitope escape mutants.

Chua, Ming Ming; MacNamara, Katherine C; San Mateo, Lani; Shen, Hao; Weiss, Susan R

Chua, Ming Ming; MacNamara, Katherine C; San Mateo, Lani; Shen, Hao; Weiss, Susan R.

Affiliation

Chua MM; Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.

J Virol ; 78(3): 1150-9, 2004 Feb.

Article in En | MEDLINE | ID: mdl-14722270

Subject(s)

Antigens, Viral/immunology; CD8-Positive T-Lymphocytes/immunology; Central Nervous System Viral Diseases/immunology; Epitopes/immunology; Glycoproteins/immunology; Murine hepatitis virus/immunology; Peptide Fragments/immunology; Viral Proteins/immunology; Animals; Antigens, Viral/metabolism; Central Nervous System Viral Diseases/prevention & control; Coronavirus Infections/immunology; Coronavirus Infections/prevention & control; Epitopes/genetics; Green Fluorescent Proteins; Humans; Immunization; Luminescent Proteins/genetics; Luminescent Proteins/immunology; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mice, Inbred C57BL; Murine hepatitis virus/genetics; Murine hepatitis virus/pathogenicity; Mutation; Perforin; Pore Forming Cytotoxic Proteins; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/immunology; Virus Replication

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Viral Proteins / Glycoproteins / Murine hepatitis virus / CD8-Positive T-Lymphocytes / Central Nervous System Viral Diseases / Epitopes / Antigens, Viral Limits: Animals / Humans Language: En Journal: J Virol Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

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