Expression analysis of the Candida albicans lipase gene family during experimental infections and in patient samples.
FEMS Yeast Res
; 4(4-5): 401-8, 2004 Jan.
Article
in En
| MEDLINE
| ID: mdl-14734020
ABSTRACT
Secreted lipases of Candida albicans are encoded by a gene family with at least 10 members (LIP1-LIP10). The expression pattern of this multigene family was investigated using reverse transcription polymerase chain reaction in experimental infections and in samples of patients suffering from oral candidosis. The findings illustrate that individual lipase genes are differentially regulated in a mouse model of systemic candidosis with some members showing sustained expression and others being transiently expressed or even silent. The lipase gene expression profile depended on the stage of infection rather than on the organ localization. This temporal regulation of lipase gene expression was also detected in an experimental model of oral candidosis. Furthermore, the expression of candidal lipase genes in human specimens is shown for the first time.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Candida albicans
/
Candidiasis
/
Isoenzymes
/
Lipase
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
FEMS Yeast Res
Journal subject:
MICROBIOLOGIA
Year:
2004
Document type:
Article
Affiliation country:
Germany