Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity.

Clark, Lisa B; Viswanathan, Palaniswamy; Quigley, Gloria; Chiang, Yueh-Chin; McMahon, Jeffrey S; Yao, Gang; Chen, Junji; Nelsbach, Andreas; Denis, Clyde L

Clark, Lisa B; Viswanathan, Palaniswamy; Quigley, Gloria; Chiang, Yueh-Chin; McMahon, Jeffrey S; Yao, Gang; Chen, Junji; Nelsbach, Andreas; Denis, Clyde L.

Affiliation

Clark LB; Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham, New Hampshire 03824, USA.

J Biol Chem ; 279(14): 13616-23, 2004 Apr 02.

Article in En | MEDLINE | ID: mdl-14734555

Subject(s)

Leucine Zippers/physiology; Proteins/metabolism; Ribonucleases/genetics; Ribonucleases/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Saccharomyces cerevisiae/enzymology; Amino Acid Sequence; Enzyme Activation; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding/physiology; Protein Structure, Secondary; Protein Structure, Tertiary; RNA, Messenger/metabolism; Ribonucleases/chemistry; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae Proteins/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Ribonucleases / Saccharomyces cerevisiae / Proteins / Leucine Zippers / Saccharomyces cerevisiae Proteins Type of study: Prognostic_studies Language: En Journal: J Biol Chem Year: 2004 Document type: Article Affiliation country: United States Country of publication: United States

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