Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction.

Martínez de Lagrán, M; Altafaj, X; Gallego, X; Martí, E; Estivill, X; Sahún, I; Fillat, C; Dierssen, M

Martínez de Lagrán, M; Altafaj, X; Gallego, X; Martí, E; Estivill, X; Sahún, I; Fillat, C; Dierssen, M.

Affiliation

Martínez de Lagrán M; Programme of Genes and Disease, Center for Genomic Regulation, 08003 Barcelona, Spain.

Neurobiol Dis ; 15(1): 132-42, 2004 Feb.

Article in En | MEDLINE | ID: mdl-14751778

Subject(s)

Brain/metabolism; Down Syndrome/complications; Movement Disorders/genetics; Protein Serine-Threonine Kinases/metabolism; Protein-Tyrosine Kinases/metabolism; Animals; Brain/pathology; Brain/physiopathology; Disease Models, Animal; Female; Gene Expression Regulation/genetics; Lameness, Animal/genetics; Lameness, Animal/metabolism; Lameness, Animal/physiopathology; Learning Disabilities/genetics; Learning Disabilities/metabolism; Learning Disabilities/physiopathology; Male; Mice; Mice, Transgenic; Motor Activity/genetics; Movement Disorders/metabolism; Movement Disorders/physiopathology; Muscle Weakness/genetics; Muscle Weakness/metabolism; Muscle Weakness/physiopathology; Neurons/metabolism; Neurons/pathology; Phenotype; Protein Serine-Threonine Kinases/genetics; Protein-Tyrosine Kinases/genetics; Dyrk Kinases

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Protein-Tyrosine Kinases / Protein Serine-Threonine Kinases / Down Syndrome / Movement Disorders Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2004 Document type: Article Affiliation country: Spain

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