Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood.

Kriangkum, Jitra; Taylor, Brian J; Treon, Steven P; Mant, Michael J; Belch, Andrew R; Pilarski, Linda M

Kriangkum, Jitra; Taylor, Brian J; Treon, Steven P; Mant, Michael J; Belch, Andrew R; Pilarski, Linda M.

Affiliation

Kriangkum J; Department of Medicine, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.

Blood ; 104(7): 2134-42, 2004 Oct 01.

Article in En | MEDLINE | ID: mdl-14764523

Subject(s)

Immunoglobulin M/genetics; Immunologic Memory; VDJ Recombinases/genetics; Waldenstrom Macroglobulinemia/immunology; Antigens/chemistry; Antigens, CD20/biosynthesis; Bone Marrow Cells/cytology; Bone Marrow Cells/metabolism; Complementarity Determining Regions/metabolism; DNA/metabolism; Genes, Immunoglobulin; Humans; Immunoglobulin M/chemistry; Immunoglobulin Variable Region; Membrane Glycoproteins/biosynthesis; Models, Genetic; Mutation; Proteoglycans/biosynthesis; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Syndecan-1; Syndecans; Tumor Necrosis Factor Receptor Superfamily, Member 7/biosynthesis; Waldenstrom Macroglobulinemia/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin M / Waldenstrom Macroglobulinemia / VDJ Recombinases / Immunologic Memory Type of study: Prognostic_studies Limits: Humans Language: En Journal: Blood Year: 2004 Document type: Article Affiliation country: Canada Country of publication: United States

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