Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D.
Cell Mol Life Sci
; 61(3): 292-300, 2004 Feb.
Article
in En
| MEDLINE
| ID: mdl-14770294
ABSTRACT
The semaphorin proteins were identified originally as axonal guidance factors functioning during neuronal development. In addition to this function, several semaphorins play diverse roles outside the nervous system. The class 4 semaphorin CD100/Sema4D, which utilizes plexin-B1 and CD72 as receptors, exerts important biological effects on a variety of cells, including the neuronal, epithelial and immune cells. Here, we review recent advances exploring the molecular mechanisms governing the biological functions of CD100/Sema4D.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membrane Glycoproteins
/
Signal Transduction
/
Receptors, Cell Surface
/
Semaphorins
/
Nerve Tissue Proteins
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Mol Life Sci
Journal subject:
BIOLOGIA MOLECULAR
Year:
2004
Document type:
Article
Affiliation country:
Japan