In vitro metabolism of ethoxidine by human CYP1A1 and rat microsomes: identification of metabolites by high-performance liquid chromatography combined with electrospray tandem mass spectrometry and accurate mass measurements by time-of-flight mass spectrometry.

Deroussent, Alain; Ré, Micheline; Hoellinger, Henri; Vanquelef, Enguerran; Duval, Olivier; Sonnier, Michèle; Cresteil, Thierry

Deroussent, Alain; Ré, Micheline; Hoellinger, Henri; Vanquelef, Enguerran; Duval, Olivier; Sonnier, Michèle; Cresteil, Thierry.

Affiliation

Deroussent A; IFR54, Institut Gustave Roussy, Pavillon de recherche, 94805 Villejuif, France. alain.deroussent@igr.fr

Rapid Commun Mass Spectrom ; 18(4): 474-82, 2004.

Article in En | MEDLINE | ID: mdl-14966856

Subject(s)

Chromatography, High Pressure Liquid/methods; Cytochrome P-450 CYP1A1/metabolism; Microsomes, Liver/metabolism; Phenanthridines/metabolism; Spectrometry, Mass, Electrospray Ionization/methods; Animals; Cell Line; Humans; Microsomes, Liver/enzymology; Molecular Structure; Molecular Weight; Phenanthridines/chemistry; Rats; Recombinant Proteins; Sensitivity and Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Phenanthridines / Microsomes, Liver / Chromatography, High Pressure Liquid / Cytochrome P-450 CYP1A1 / Spectrometry, Mass, Electrospray Ionization Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Rapid Commun Mass Spectrom Year: 2004 Document type: Article Affiliation country: France Country of publication: United kingdom

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