Structure-activity relationships of small phosphopeptides, inhibitors of Grb2 SH2 domain, and their prodrugs.

Liu, Wang-Qing; Vidal, Michel; Olszowy, Catherine; Million, Emmanuelle; Lenoir, Christine; Dhôtel, Hélène; Garbay, Christiane

Liu, Wang-Qing; Vidal, Michel; Olszowy, Catherine; Million, Emmanuelle; Lenoir, Christine; Dhôtel, Hélène; Garbay, Christiane.

Affiliation

Liu WQ; Département de Pharmacochimie Moléculaire & Structurale, INSERM U266, CNRS FRE 2463, UFR des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, 75270 Paris 06, France.

J Med Chem ; 47(5): 1223-33, 2004 Feb 26.

Article in En | MEDLINE | ID: mdl-14971902

Subject(s)

Adaptor Proteins, Signal Transducing; Antineoplastic Agents/chemical synthesis; Phosphopeptides/chemical synthesis; Phosphotyrosine/chemistry; Prodrugs/chemical synthesis; Proteins/antagonists & inhibitors; Receptor, ErbB-2/metabolism; src Homology Domains; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Binding, Competitive; Cell Line, Tumor; Cell Transformation, Neoplastic; Esters/chemical synthesis; Esters/chemistry; Esters/pharmacology; GRB2 Adaptor Protein; Humans; Mice; Molecular Mimicry; NIH 3T3 Cells; Phosphopeptides/chemistry; Phosphopeptides/pharmacology; Prodrugs/chemistry; Prodrugs/pharmacology; Proteins/chemistry; Proteins/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Phosphopeptides / Prodrugs / Proteins / Receptor, ErbB-2 / Src Homology Domains / Phosphotyrosine / Adaptor Proteins, Signal Transducing / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Document type: Article Affiliation country: France Country of publication: United States

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