[Pathophysiology and therapy of L-Dopa-induced dyskinesia]. / Physiopathologie et modalités thérapeutiques des dyskinésies induites à la L-Dopa.
Rev Neurol (Paris)
; 159(12): 1125-42, 2003 Dec.
Article
in Fr
| MEDLINE
| ID: mdl-14978413
ABSTRACT
Involuntary movements, or dyskinesias, represent a debilitating complication of levodopa therapy for Parkinson's disease. Dyskinesia is, ultimately, experienced by the vast majority of the patients. Despite the importance of this problem, little was known about the cause of dyskinesia, a situation that has dramatically evolved in the last few years. The present review presents 1) the current understanding of dyskinesia pathophysiology and 2) the therapeutic modalities, mainly non-dopaminergic, available or in development. We here show that the questions raised by the dyskinesia may have a clinically-driven pharmacological answer the symptomatic treatment of dyskinesia, the prevention of the priming and the de-priming of the neural networks.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dopamine Agents
/
Levodopa
/
Dyskinesia, Drug-Induced
Limits:
Animals
/
Humans
Language:
Fr
Journal:
Rev Neurol (Paris)
Year:
2003
Document type:
Article
Affiliation country:
Canada