Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain.

Záková, Lenka; Barth, Tomislav; Jirácek, Jirí; Barthová, Jana; Zórad, Stefan

Záková, Lenka; Barth, Tomislav; Jirácek, Jirí; Barthová, Jana; Zórad, Stefan.

Affiliation

Záková L; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of Czech Republic, Flemingovo 2, 16610 Prague, Czech Republic. zakova@uochb.cas.cz

Biochemistry ; 43(8): 2323-31, 2004 Mar 02.

Article in En | MEDLINE | ID: mdl-14979729

Subject(s)

Amino Acid Substitution; Insulin/analogs & derivatives; Insulin/chemical synthesis; Protein Subunits/chemical synthesis; Recombinant Proteins/chemical synthesis; Tyrosine; Animals; Biological Transport/genetics; Deoxyglucose/metabolism; Humans; Hydrogen Bonding; Insulin/metabolism; Male; Methylation; Peptide Fragments/chemical synthesis; Peptide Fragments/metabolism; Phenylalanine/chemistry; Protein Binding; Protein Structure, Tertiary; Protein Subunits/metabolism; Rats; Rats, Wistar; Receptor, Insulin/metabolism; Recombinant Proteins/metabolism; Swine; Tyrosine/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Tyrosine / Recombinant Proteins / Amino Acid Substitution / Protein Subunits / Insulin Limits: Animals / Humans / Male Language: En Journal: Biochemistry Year: 2004 Document type: Article Affiliation country: Czech Republic Country of publication: United States

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